Many biological processes are regulated via environmentally-controlled protein/protein interactions. Initiated by changes at bound cofactors, these alterations affect protein conformations and regulation via in cis or in trans control of catalytic domains or multiprotein complexes.

To characterize novel aspects of such protein structure/function control, we are comparing the structures, dynamics and functions of members of several classes of ligand-regulated protein/protein interaction domains. We combine biophysical (NMR, X- ray crystallography, spectroscopy), biochemical and chemical approaches, integrating data from isolated protein domains with full length proteins in living cells.

Here you'll find information about these concepts in practice, via our studies of photosensors, components of the hypoxia response, and others. Please drop me an email if you have any questions or comments - Kevin Gardner, Sept 2009